Why Exercise Slows Aging | Lifespan with Dr. David Sinclair

About this episode

At Lifespan, our mission is to help you and your loved ones live your longest, healthiest lives while supporting medical research into breakthroughs to improve all lives. We’re building the world’s largest longevity community: Join us at https://lifespan.com. Follow us on YouTube, Apple, and Spotify for new Lifespan episodes every 2 weeks. __________________________________________ This episode explores why humans are biologically built to move and what happens to the aging process when we don’t. Drawing on evolutionary biology and the latest research, Dr. Sinclair traces physical activity back millions of years, explaining how humans evolved for endurance, why modern sedentary life creates a profound mismatch with our biology, and how exercise activates ancient cellular pathways involved in repair, resilience, metabolism, and longevity. Dr. Sinclair breaks down what happens inside the body when we exercise, including the molecular responses that help us adapt to stress and influence the brain, immune system, metabolism, cardiovascular health, and even the way our cells age. He also tackles some of the biggest questions i